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Unintentional overdose due to misadministration has been reported in infants and children with the use of Reglan syrupWhile there was no consistent pattern to the reports associated with these overdosesevents included seizuresextrapyramidal reactionsand lethargy.
Experience with esophageal erosions and ulcerations is limitedbut healing has thus far been documented in one controlled trial using q.i.dtherapy at 15 mg/doseand this regimen should be used when lesions are presentso long as it is toleratedsee ADVERSE REACTIONSBecause of the poor correlation between symptoms and endoscopic appearance of the esophagustherapy directed at esophageal lesions is best guided by endoscopic evaluation.
The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy.
Care should be exercised in administering metoclopramide to neonates since prolonged clearance may produce excessive serum concentrationssee CLINICAL PHARMACOLOGYPharmacokineticsIn additionneonates have reduced levels of NADH-cytochrome b 5 reductase whichin combination with the aforementioned pharmacokinetic factorsmake neonates more susceptible to methemoglobinemiasee OVERDOSAGE
Mental depression has occurred in patients with and without prior history of depressionSymptoms have ranged from mild to severe and have included suicidal ideation and suicideMetoclopramide should be given to patients with a prior history of depression only if the expected benefits outweigh the potential risks.
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